Medulloblastoma Spatial Transcriptomics Reveals Tumor Microenvironment Heterogeneity with High-Density Progenitor Cell Regions Correlating with High-Risk Disease
July 9, 2024Denis’s Paper Wins Best Oral Presentation at MD/PhD Conference!
July 18, 2024
We’re thrilled to share the preprint of our article titled “Single-cell analysis of pediatric acute myeloid leukemia samples uncovers treatment-resistant stem and mast cells” on bioRxiv. Check it out at https://www.biorxiv.org/content/10.1101/2024.07.09.602801
Big thanks to Denis Ohlstrom for leading the effort and performing excellent analysis in collaboration with other lab members and collaborators: Mojtaba Bakhtiary, Hope Mumme, Marina Michaud, Frank Chien, William Pilcher, Sarthak Satpathy, Sean Jordan, and Swati Bhasin!
This article describes the largest single-cell RNA sequencing analysis of pediatric acute myeloid leukemia (pAML) to date, totaling 164 bone marrow biopsies. The study uncovered a novel association of treatment-resistant mast-like malignant cells with poor outcomes in core binding factor mutations containing pediatric AML.
