Diabetic Foot Ulcer Publication Alert!

We’re excited to announce the publication of our article, “Single-cell Analysis of Debrided Diabetic Foot Ulcers Reveals Dysregulated Wound Healing Environment in non-Hispanic Blacks ” in the prestigious Journal of Investigative Dermatology. The study demonstrated that debridement samples of healing diabetic Foot Ulcers (DFUs) were significantly enriched with distinct fibroblasts expressing genes related to inflammation (CHI3L1, IL6) and extracellular matrix remodeling (ASPN), validating our previous studies on surgically resected ulcers. Further, race-focused analysis depicted lower expression of key healing-associated genes in non-Hispanic Black compared to White patients. Our findings advocate race as a risk marker of diverse DFU outcomes, likely reflecting underlying disparities in environmental exposures and access to care that profoundly influence healing markers.

Read the full article at https://www.sciencedirect.com/science/article/abs/pii/S0022202X24019791

We would like to thank Dahim Choi for leading this effort and everyone else in the Bhasin Lab that helped contribute to this publication!