Recent News

We’re excited to announce the publication of our article, “Single-cell Analysis of Debrided Diabetic Foot Ulcers Reveals Dysregulated Wound Healing Environment in non-Hispanic Blacks ” in the prestigious Journal of Investigative Dermatology. The study demonstrated that debridement samples of healing diabetic Foot Ulcers (DFUs) were significantly enriched with distinct fibroblasts expressing genes related to inflammation (CHI3L1, IL6) and extracellular matrix remodeling (ASPN), validating our previous studies on surgically resected ulcers. Further, race-focused analysis depicted lower expression of key healing-associated genes […]

Congrats to Denis Ohlstrom, whose presentation titled “Malignant mast cells are chemoresistant and associated with shortened overall survival in core binding factor mutated pediatric acute myeloid leukemia” won the award for best oral presentation! Way to go Denis! You’re making the lab proud!  

We’re thrilled to share the preprint of our article titled “Single-cell analysis of pediatric acute myeloid leukemia samples uncovers treatment-resistant stem and mast cells” on bioRxiv. Check it out at https://www.biorxiv.org/content/10.1101/2024.07.09.602801 Big thanks to Denis Ohlstrom for leading the effort and performing excellent analysis in collaboration with other lab members and collaborators: Mojtaba Bakhtiary, Hope Mumme, Marina Michaud, Frank Chien, William Pilcher, Sarthak Satpathy, Sean Jordan, and Swati Bhasin! This article describes the largest single-cell RNA sequencing analysis of pediatric […]

Our article titled “Medulloblastoma Spatial Transcriptomics Reveals Tumor Microenvironment Heterogeneity with High-Density Progenitor Cell Regions Correlating with High-Risk Disease” is now online at bioRxiv! Here is the link: https://www.biorxiv.org/content/10.1101/2024.06.25.600684v1.   Huge thanks to Franlin Chien, Marina Michaud, and Mojtaba Bakhtiari for leading this analysis!