September 29, 2025
CONCLUSION: This study did not find any significant between-group effects with any outcome measures. The null findings in this study might have been due to floor effects from the study sample of healthy adults.
September 23, 2025
Spinal Muscular Atrophy (SMA) is a neurodegenerative disorder primarily affecting motor neurons, but immune dysfunction may contribute to disease progression and treatment response. While AAV9-delivered SMN1 gene therapy (e.g., Zolgensma) improves survival, long-term motor outcomes remain variable. This study integrates bulk and single-cell RNA sequencing (scRNA-seq) to define immune dysregulation in SMA. We analyzed peripheral blood from infants with SMA (n = 7 for bulk RNA-seq; n = 4 for...
September 19, 2025
September 10, 2025
Pediatric acute myeloid leukemia (pAML) is a heterogeneous malignancy driven by diverse cytogenetic mutations. While identification of cytogenetic lesions improved risk stratification, prognostication remains inadequate with 30% of standard-risk patients experiencing relapse within 5 years. To deeply characterize pAML heterogeneity and identify poor outcome-associated blast cell profiles, we performed an analysis on 708,285 cells from 164 bone marrow biopsies of 95 patients and 11 healthy...
May 25, 2025
Meditation training has been shown to improve physical and mental health and promote neural plasticity, but more research is needed on the relationships between these effects. This study analyzed the Resting State Functional Connectivity (RSFC) of posterior cingulate cortex (PCC) among 94 chronically stressed but otherwise healthy adults randomized 1:1:1 to receive eight weeks of in-person one-on-one interventions focused either on meditation (n = 32), yoga (n = 31), or stress education (n =...
May 9, 2025