Sean Jordan – Page 2

August 10, 2024

Single-cell Analysis of Debrided Diabetic Foot Ulcers Reveals Dysregulated Wound Healing Environment in non-Hispanic Blacks

Diabetic foot ulcer (DFU) is a critical complication of diabetes, but the wound microenvironment and its healing process are not completely understood. In this study, we optimized single-cell profiling from sharp debrided ulcers. Our findings demonstrate that healing-DFUs were significantly enriched with distinct fibroblasts expressing genes related to inflammation (CHI3L1, IL6) and extracellular matrix remodeling (ASPN), validating our previous studies on surgically resected ulcers. The...

July 18, 2024

Denis’s Paper Wins Best Oral Presentation at MD/PhD Conference!

Congrats to Denis Ohlstrom, whose presentation titled “Malignant mast cells are chemoresistant and associated with shortened overall survival in core binding factor mutated pediatric acute myeloid leukemia” won the award for best oral presentation! Way to go Denis! You’re making the lab proud!

July 11, 2024

Pediatric AML paper is on bioRxiv!

We’re thrilled to share the preprint of our article titled “Single-cell analysis of pediatric acute myeloid leukemia samples uncovers treatment-resistant stem and mast cells” on bioRxiv. Check it out at https://www.biorxiv.org/content/10.1101/2024.07.09.602801 Big thanks to Denis Ohlstrom for leading the effort and performing excellent analysis in collaboration with other lab members and collaborators: Mojtaba Bakhtiary, Hope Mumme, Marina Michaud, Frank Chien, William Pilcher, Sarthak Satpathy, Sean Jordan, and Swati Bhasin! This article describes the largest single-cell RNA sequencing analysis of pediatric […]

July 9, 2024

Medulloblastoma Spatial Transcriptomics Reveals Tumor Microenvironment Heterogeneity with High-Density Progenitor Cell Regions Correlating with High-Risk Disease

The tumor microenvironment (TME) of medulloblastoma (MB) influences progression and therapy response, presenting a promising target for therapeutic advances. Prior single-cell analyses have characterized the cellular components of the TME but lack spatial context. To address this, we performed spatial transcriptomic sequencing on sixteen pediatric MB samples obtained at diagnosis, including two matched diagnosis-relapse pairs. Our analyses revealed inter- and intra-tumoral heterogeneity within...