Sean Jordan – Page 8

November 14, 2023

Integrated single-nuclei and spatial transcriptomic analysis reveals propagation of early acute vein harvest and distension injury signaling pathways following arterial implantation

CONCLUSIONS: Vein conduit harvest and distension elicit a prompt genomic response facilitated by distinct cellular subpopulations heterogeneously distributed throughout the vein wall. This response was found to be further exacerbated following vein graft implantation, resulting in a cascade of maladaptive gene regulatory networks. Together, these results suggest that distension initiates the upregulation of pathological pathways that may ultimately contribute to bypass graft failure and presents...

October 16, 2023

Single-cell RNA sequencing distinctly characterizes the wide heterogeneity in pediatric mixed phenotype acute leukemia

CONCLUSIONS: We have for the first time described the single-cell transcriptomic landscape of pediatric MPAL and demonstrated that B/My and T/My MPAL have distinct scRNAseq profiles from each other, AML, and ALL. Differences in transcriptomic profiles were seen based on response to therapy, but larger studies will be needed to validate these findings.

October 5, 2023

The Bhasin Lab Welcomes Baby Cameron!

Congratulations to Frank Chien and his wife on giving birth to a beautiful baby boy, Cameron Isaac Chien! We wish him and his wife the best in starting their new family together!

October 5, 2023

Breast Cancer Paper Published in PLOS Biology

Congratulations to Moji, Swati, Beena, and Manoj, who recently had their paper “Taxane chemotherapy induces stromal injury that leads to breast cancer dormancy escape” published in PLOS Biology! Check it out here: https://doi.org/10.1371/journal.pbio.3002275.