Sean Jordan – Page 6

October 16, 2023

Single-cell RNA sequencing distinctly characterizes the wide heterogeneity in pediatric mixed phenotype acute leukemia

CONCLUSIONS: We have for the first time described the single-cell transcriptomic landscape of pediatric MPAL and demonstrated that B/My and T/My MPAL have distinct scRNAseq profiles from each other, AML, and ALL. Differences in transcriptomic profiles were seen based on response to therapy, but larger studies will be needed to validate these findings.

October 5, 2023

The Bhasin Lab Welcomes Baby Cameron!

Congratulations to Frank Chien and his wife on giving birth to a beautiful baby boy, Cameron Isaac Chien! We wish him and his wife the best in starting their new family together!

October 5, 2023

Breast Cancer Paper Published in PLOS Biology

Congratulations to Moji, Swati, Beena, and Manoj, who recently had their paper “Taxane chemotherapy induces stromal injury that leads to breast cancer dormancy escape” published in PLOS Biology! Check it out here: https://doi.org/10.1371/journal.pbio.3002275.

October 5, 2023

Single-cell analysis reveals altered tumor microenvironments of relapse- and remission-associated pediatric acute myeloid leukemia

Acute myeloid leukemia (AML) microenvironment exhibits cellular and molecular differences among various subtypes. Here, we utilize single-cell RNA sequencing (scRNA-seq) to analyze pediatric AML bone marrow (BM) samples from diagnosis (Dx), end of induction (EOI), and relapse timepoints. Analysis of Dx, EOI scRNA-seq, and TARGET AML RNA-seq datasets reveals an AML blasts-associated 7-gene signature (CLEC11A, PRAME, AZU1, NREP, ARMH1, C1QBP, TRH), which we validate on independent datasets. The...